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PMC 4260154

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Each subunit contains a non-covalently bound flavin adenine dinucleotide (FAD) and several cysteine pairs which are thought to participate in series in the displacement of electrons within the enzyme by disulfide exchange reactions (Figure 1) (Sandalova et al., 2001

97 Notably, GPX4 expression did not significantly affect TGF-1-induced EMT in A549 cells, nor did it reverse erastin-induced ferroptosis