However, limitations such as regulatory uncertainty, scale-up challenges, and long-term safety remain barriers to clinical adoption
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Statistical Analysis The data were analyzed using (STATA 14 software, College Station, TX, United States) (Stata Corp, College Station, TX, United States)
doi: 10.5582/bst.2018.01293 42 JiangLYuanXYangNRenLZhaoFLuoBet al
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Remarkably, the intracellular ER localization of the enzyme appears to require the signal peptide, and without it, the protein might not be properly synthesized or be rapidly degraded, as no stable protein was observed for the N form (Fig