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Taylor, L

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The in vitro biological effects of CB-839 have been tested more extensively in multiple myeloma (24), AML (10, 11), and T-cell acute lymphoblastic leukemia cell lines and primary blasts (29)

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To generate the CRISPR/Cas9-engineered Gmmorf2a/b mutant, gRNAs were designed using the CRISPR-P website ( Two 20-bp DNA fragments coding for the gRNA were inserted into the pCas9-MDC-sgRNA plasmid

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