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It is an energy-dependent process characterized by cell shrinkage, cytoskeletal disruption, membrane blebbing, chromatin condensation, nuclear and DNA fragmentation

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

Since most chemotherapeutic agents increase intracellular ROS levels [47], TIC resistance may stem from their high antioxidant content, including glutathione

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doi: 10.1038/12469

In-house cell laboratory cells prepared and administered on-site