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We showed that blocking GGT activity slows tumour growth by depriving it of intracellular cysteine

Surprisingly, increased p21 level was observed in the FOXO4-DRI pre- treatment groups, suggesting senolytics might be a potential stressor to cells

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Additionally, the level of the mitochondrial glutamine transporter controls the cellular ATP level stimulated by glutamine, suggesting that glutamine is an important energy source via mitochondrial glutaminolysis 16