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For instance, the receptors of IL-6, IL-10, IL-23, interferons, EGF, and Ins/IGF-1 as well as certain G-protein coupled receptors (GPCR) are linked to the activation of JAK1/JAK2 which subsequently recruit STAT3 proteins to the receptor complex and phosphorylate STAT3 at Tyr705 [37]

Metabolic benefits beyond weight loss Weight loss is the headline, but both medications produce metabolic improvements that extend far beyond the number on the scale

Collectively, this study and others that are conducted with this global team of experts focused on unraveling the biological mechanisms of konzo operates at the highest standards of inclusion, ethical considerations, participant safety and authorship, with the goal of bringing global attention to konzo and other neglected diseases that burden the worlds most impoverished populations

10.1038/ncomms14108 54 SpinelliS.MarinoA.MorabitoR.RemiganteA

Sabirov D

Aging Cell 20 , e13328 (2021)