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Licorice flavonoids showed strong inhibitory effects on Bel-7402 cancer cells, among which ISL exhibited the greatest potency against Bel-7402 (IC50 = 0.7 0.11 mol/L), which was 3-fold more potent than flavopiridol (2.4 0.34) mol/L in an antitumor activity of licorice flavonoids (Zhang and Li, 2018)

The kinetic rate was measured at A 412 for 5 min

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N Engl J Med (2016) 375(16):155265

Reactions don't improve with continued use