While drugs targeting ferroptosis hold promise, they also present challenges: (I) lack of specificity: where iron chelators may disrupt normal cellular iron metabolism and cause iron-deficiency anemia
However, those with liver or kidney disease, pregnant women or patients undergoing intensive treatments should consult their physician first
Thus, the negative regulation of gliotoxin biosynthesis via GtmA must be counter-balanced by GliT activity to avoid Methyl/Met cycle dysregulation, SAM depletion and trans consequences on global cellular biochemistry in A

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Journal Oncology 65 (1), 70
Also, in response to pathogens, there is often accumulation of mitochondrial ROS which can impact the GSH:GSSG ratio in this organelle