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Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts

(2024, CNS Neuroscience & Therapeutics ) confirmed ARA-290 provided neuroprotective effects in a mouse MCAO (middle cerebral artery occlusion) model comparable to full-length EPO, significantly reducing neuronal apoptosis and inflammatory cytokines, confirmed to act via CR without stimulating erythropoiesis Blood-brain barrier (BBB) penetration confirmed in pre-clinical studies

ER, estrogen receptor

Instead, it is studied through several overlapping marker systems, including angiogenesis, nitric oxide signalling, VEGF related markers, fibroblast migration, collagen organisation, tendon fibroblast activity, inflammatory mediators and gastrointestinal mucosal models