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Moreover, an enormous amount of time, labor, and cost are needed to optimize and improvements needed to translate each stimulus-based NM from the preclinical to clinical stage apart from endogenous triggers such as pH and temperature, as this varies depending from one person to another

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Previous work has also shown that high pressure and low temperature have the same response on membrane fluidity, causing an increase in the proportion of unsaturated fatty acids in their lipids

While the comparative advantages of tripeptides over larger peptides highlight their therapeutic potential, it is through specific examples that their true value becomes evident