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Without liver transplant, acute liver failure due to idiosyncratic drug injury carries a high mortality rate (up to 80%) If encephalopathy or coagulopathy develops in patients who have hepatocellular DILI and jaundice, they should be referred to a liver transplant center Pharmacogenetics There is considerable interest in identifying the genes that contribute to DILI

Although heavy metal lacks a consistent definition in medical and scientific literature, the term is commonly used to describe the group of dense metals or their related compounds, usually associated with environmental pollution or toxicity

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SUSTAIN-6, 2016 GLP-1 receptor signaling in the hypothalamus and hindbrain modulates satiety and food-reward pathways, a focus of ongoing neuroscience research

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