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In cell-based and animal studies, GHRH-receptor agonism (tesamorelin) and GHS-R1a agonism (ipamorelin) have been reported to engage different intracellular signaling cascades that both terminate in growth-hormone secretion, an arrangement investigators have explored for potentially amplified, rather than simply additive, secretory responses

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GH & IGF-1 support Studied for stimulating pulsatile growth hormone release, pairing a ghrelin agonist with a GHRH analog to raise IGF-1

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