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If B12 blood levels and MMA are both high, a functional B12 deficiency could be preventing B12 being useful at cell/tissue level

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The cytoplasmic segment mainly includes -catenin, DVL, glycogen synthase kinase-3 (GSK-3), AXIN, APC, and casein kinase I (CK1)

doi: 10.1007/s40120-024-00629-2 51

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Furthermore, treatment with VE in dogs caused the reduction of IL-1, a cytokine that has the potential to cause atherosclerosis, as well as a suppression of monocyte-endothelial cell adhesion, an essential component of the atherogenic process (50)