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[29] The observed PD-L1 reduction in URPL may represent a pathological failure of this immunosuppressive checkpoint, weakening physiological restraint on T cells and permitting unrestrained hyperactivation

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Figure 4 5 Muscle cramps 5.1 Prevalence and mechanisms Muscle cramps are involuntary, at times visible, and painful contractions of skeletal muscles that can occur at rest or be intense enough to awaken a person from sleep

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