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First, participants reported feeling like they had returned to their teenage years in terms of energy levels and skin clarity

J Hebei Traditional Chin Med Pharmacol

While I did not try ablative lasers, aggressive treatments that work by removing and rebuilding the outer layer of the skin, I tried non-ablative lasers (like Clear + Brilliant), chemical peels (such as the VI Peel, which initially was successful at lightening my melasma, but unfortunately didnt have a lasting effect), and an array of other skin care including tretinoin (a prescription retinoid) and glycolic acid

Metabolites 10 (11), 450

However, once they are stopped, the major studies show that patients regain most of the weight lost

No human trials as of June 2026