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Participants receiving 2.4mg weekly semaglutide lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group

Taken together, this review provides a rationale for the use of trimetazidine as a promising repurposing candidate to treat bipolar depression

Moreover, MAPK/ERK signaling upregulates Kruppel-like factor-2 (KLF2) and KLF4, which enhance eNOS expression, inhibit NF-B signaling, and suppress TNF- receptor expression, reinforcing anti-inflammatory and atheroprotective effects [207]

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