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The techniques of CT segmentation, computer-aided design of the implant, and fabrication of custom-made anatomical titanium prostheses for reconstruction are feasible, safe and provide satisfactory results

In addition to the genetic information encoded by the primary DNA sequence, epigenetic mechanisms add a layer of regulation of the information and includes DNA methylation, histone modifications as well as regulation by non-coding RNAs (Esteller, 2008

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