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Yes, it is very safe

Li et al [8] used a similar density gradient in which the densest 42% (w/v) iodixanol layer was replaced by a 36% (w/v) iodixanol layer, was used for the fractionation of cells from the green sea urchin Strongylocentrotus droebachiensis

Final Considerations Regarding General Concerns Notably, the specific points discussed before might still indicate general concern [1]

Using more than necessary can be counterproductive