Positive and negative aspects of l-carnitine supplementation need to be clarified, especially considering its metabolite trimethylamino- N -oxide, which may be associated with the etiology of some diseases [61]
Ruland J
Aboudalle I, Kantarjian H, Ohanian M, Alvarado Y, Jabbour EJ, Garcia-Manero G, Naqvi K, Wierda WG, Daver NG, Burger JA, Konopleva MY, Takahashi K, Andreeff M, Pemmaraju N, Ferrajoli A, Borthakur G , Kadia TM, Ravandi F, Cortes JE
Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity
Key roles include: Antioxidant defense: Neutralizes free radicals and reactive oxygen species (ROS) before they damage cell membranes, proteins, and DNA
They help with muscle growth, tissue repair, enzyme production, and hormone regulation