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Common reactions include: Stomach issues (nausea, diarrhea, bloating) Headaches Fatigue Skin reactions (flushing, rashes) Animal studies using high doses have shown possible liver toxicity, mainly because the liver produces high levels of NNMT (nicotinamide N-methyltransferase), making it sensitive to excess nicotinamide [38]

6 Discussion This review provides a comprehensive overview of the regulatory effects of flavonoids on immune cell functions and their strategic applications in the management of inflammatory disorders ( Figures 1 and 2 )

Occasional mild injection-site reactions (redness/itch) may occur with subcutaneous administration

Socioeconomic status and incident type 2 diabetes mellitus: Data from the Women's Health Study

However, alcohol, like food, affects insulin release

Phytomedicine 2022;104:154250