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ROS signaling regulates transcription factors, such as AP-1 and nuclear factor-kappa B (NF-B), inducing the expression of matrix metalloproteinases (MMPs) that can induce collagen oxidation and reduce the expression of types I and III collagen [26]

The two have never been tested against each other, and the headline figures (roughly 20.4% vs 20.9%) come from different trials in different populations

Additionally, the concentration of AOD9604 in the synovial fluid after injection was estimated to be about 0.19 mg/mL, similar to concentrations used in previous GH injection studies in animal models