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According to the mechanism study, baicalein could downregulate downstream important glycolytic enzymes (HK2, LDH-A, PDK1) by encouraging the accumulation of intracellular PTEN and inhibiting the activation of the PI3K/Akt signaling, thereby reversing the hypoxia-induced 5-Fu resistance (115)

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No specific interactions have been documented that make these combinations dangerous

Furthermore, ADE and ERD has been reported for SARS-CoV and MERS-CoV both in vitro and in vivo