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CabreraRAUsryJLArrellanoCNogueiraETKutschenkoMMoeserAJet al

The biomedical significance of homocysteine

In LOsG-induced prediabetes, although pancreatic ROS stress remained high on LOsG treatment day 38, there were no alterations in mRNA levels of ER stress (XBP1 and BIP), inflammation (IL6 and IL1), and hypoxia-responsive (HIF1 and GAPDH) genes between LOsG- and sham-treated groups

These structural insults further limit a cells ability to detoxify and recover from oxidative stress

10.1016/j.gene.2017.04.048 Gene 34 CamargoA.RodriguesA

On the other hand, there was a significant increase in the levels of oxidized GSH (GSSG) in the plasma ( Figure 4I ), PBMCs ( Figure 4J ) and RBCs ( Figure 4K ) samples from individuals with T2DM at 3-months post-placebo supplementation