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They are also known for inhibition of various enzymes e.g., enzymes of lipoxygenase and cyclooxygenase pathway 65 and glutathione S-transferase, NADH oxidase and mitochondrial succinoxidase, all involved in the generation of ROS 66

[DOI] [PubMed] [Google Scholar] 149.Breier A., Liffick E., Hummer T.A., Vohs J.L., Yang Z., Mehdiyoun N.F., Visco A.C., Metzler E., Zhang Y., Francis M.M

The major drawback of both -LA and DHLA are their pro-oxidant effects which have been observed to occur under certain circumstances and result in the peroxidation of lipids

Prim Care 45(2):237255 Liu P, Wang J, Wen W, Pan T, Chen H, Fu Y, Wang F, Huang JH, Xu S (2020) Cinnamaldehyde suppresses NLRP3 derived IL-1 via activating succinate/HIF-1 in rheumatoid arthritis rats

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