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In contrast, CHAC1-driven GSH degradation reduces protein SSG, enhances transferrin receptor (TFRC)mediated iron uptake, and exacerbates ferroptosis, whereas hemoglobin SSG shields reactive cysteine residues from excessive oxidation 127,128

In cancer cells, genetic and epigenetic dysregulation of MYC expression and the loss of checkpoint components unleash the ability of MYC to promote cell growth, eventually leading to malignant transformation 176

Notably, phentermine was one of the ingredients in fen-phen (fenfluramine/phentermine), a drug that researchers linked to serious valvular heart problems in the 1990s

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