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Authors:Clavreul N, Adachi T, Pimental DR, Ido Y, Schneich C, Cohen RA Journal:FASEB J PubMed ID:16415107 'The highly reactive species, peroxynitrite, is produced in endothelial cells in pathological states in which the production of superoxide anion and NO is increased

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CKD is often not detected until it has reached an advanced stage (NIH 2008

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Louis, MO) under the condition of 37 C in a humidified atmosphere of 5% CO 2

Subsequent investigations examined genes functionally linked to OA by assessing promoter methylation and mRNA expression in cartilage tissue, primary chondrocytes, and chondrocyte cell lines