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Funding This work was financially supported by the National Natural Science Foundation of China (82071434), the Natural Science Foundation of Jiangsu Province (BK20201490), Nanjing Medical University Specific Disease Cohort Study Project (JX218GSP20211804A), Jiangsu Province Six Talent Peak High-Level Talent Selection and Training Programme (WSN-004), the 511 Project, and Jiangsu Province Hospital (the First Affiliated Hospital with Nanjing Medical University) Clinical Capacity Enhancement Project