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Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation

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The use of hydroxocobalamin became first line due to its low adverse risk profile, rapid onset of action, and ease of use in the prehospital setting

These occur alongside shared neurodegenerative processes such as mitochondrial dysfunction, oxidative stress, and neuroinflammation

Feb 14 2022;29(4):465-482

Overview Glutathione (-L-glutamyl-L-cysteinyl-glycine) is a tripeptide synthesized intracellularly from glutamate, cysteine, and glycine by the sequential action of -glutamylcysteine synthetase and glutathione synthetase