Certain muscles, such as skeletal muscles, are metabolically active and contribute to a major part of resting energy expenditure
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The highly variable clinical presentation of depression, difficulty in estimating its course and prognosis, and slow response and side effects of antidepressant treatment (e.g., nausea, headaches, liver injury, and cardiovascular disease risk) have prompted the search for novel, multitargeted, safe, and effective antidepressants [17]
For instance, muscle biopsies from ME/CFS patients have revealed cellular membrane damage, likely attributable to elevated levels of ROS (Pietrangelo et al., 2018)
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