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The results of immunohistochemistry indicated that, compared with the normal group, the saline group exhibited the highest expression levels of IL-1 and TNF-, alongside the lowest expression levels of IL-10 and TGF- (Fig

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In contrast, if the calpain inhibitors are targeting mainly ATXN3 cleavage, they should be ineffective in SCA3 disease models expressing cleaved ATXN3 to start with