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We also showed the correlation between iron ions and free radicals (Figure 2)

The constructed PD-L1-targeted metabolism and immunomodulator (PMIR) is used to regulate metabolism in the TME to improve immunotherapy

Particularly the pyruvate dehydrogenase kinase isoenzyme-4 gene encodes PDK that converts pyruvate, CoA and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, the reduced form of nicotinamide adenine dinucleotide (NADH) and carbon dioxide

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51, 317320.10.1111/j.1471-4159.1988.tb04872.x 113 PardoB.RodriguesT

On the one hand, ROS induce oxidative damage to cysteine residues within the MutS complex (MSH2-MSH6 heterodimer), specifically impairing its ATPase-dependent DNA mismatch recognition capacity