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Future frameworks will likely need to incorporate guidance for engineered strains, synbiotics, microbial consortia, and microbiome-based therapeutics, extending the FAO/WHO principles to more complex products while maintaining their core focus on strain specificity, safety, and evidence-based health benefits (531)

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rhGH triggered changes in kisspeptin, GnRH, and LH in immature male rats During the prepubertal period, kisspeptin activates the HPG axis and increases sex steroids [36, 37]

And that also prevents the adaptations to exercise