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That said, many people are low without any obvious symptoms

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When B12 levels are low, your body may struggle to produce these essential neurotransmitters, contributing to feelings of anxiety, irritability, and emotional instability

These effects are mediated by modulation of neurotransmitters (serotonergic, dopaminergic) and preservation of the blood-brain barrier

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Angiogenesis cuts both ways: The pro-angiogenic, pro-migration mechanisms that make these peptides interesting for repair are the same processes that are undesirable in the presence of malignancy an unresolved theoretical concern and a genuine reason for caution