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10.1186/s12915-014-0056-6 BMC Biol

In addition to this, Cui et al

A fast way to dirty up your pathways is overconsuming of carbohydrates

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Efficacy and safety of intranasal esketamine for the rapid reduction of symptoms of depression and suicidality in patients at imminent risk for suicide: results of a double-blind, randomized, placebo-controlled study

Taken together, these observations point to a future therapeutic paradigm that is inherently combinatorial: mitigation of metabolic and inflammatory stressors, protection and regeneration of endogenous -cells, and, where necessary, -cell replacement, complemented by targeted modulation of the gut microbiota