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Spanish and Portuguese colonies attempted to obtain trade with the natives

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Researchers are now targeting specific genes that may be responsible for nicotine dependence

That distinction means pouch users are less likely to get addicted to the product than are people who smoke cigarettes or vape much as people who chew coca leaves are less likely to get addicted than people who smoke crack cocaine, says Jonathan Foulds, a smoking cessation researcher at Pennsylvania State Universitys Cancer Institute

Apart from that, factors like genetics, stress, social and environmental settings, and tolerance also cause tobacco addiction