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10.1194/jlr.RA119000200 J Lipid Res

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Appl Environ Microbiol 70: 51595167

4.5 Emerging evidence on D-chiro-inositol and combined formulations Early randomized trials positioned d-chiro-inositol (DCI) as an insulin-sensitizing agent with downstream reproductive benefits (160)

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The pulsatile nature of this release is clinically significant: it mimics endogenous GH secretion rhythms, preserving downstream IGF-1 production, protein synthesis, and fat oxidation without the sustained GH elevation that can impair insulin sensitivity